Xgeva (denosumab) is a monoclonal antibody. Monoclonal antibodies target and destroy only certain cells in the body. This may help to protect healthy cells from damage.

Xgeva is used to treat bone problems that may occur in people with multiple myeloma or in people with cancer that has spread to the bones. It is also used to treat high blood levels of calcium (hypercalcemia) caused by cancer when other medicines have been used without success.

Also it may be used by adults (and teenagers who have reached their final adult height) to treat a certain disease called giant cell tumor of the bone, if they cannot use surgery to treat the disease. Prolia is another brand of denosumab used to treat osteoporosis in postmenopausal women who have high risk of bone fracture.

Some common side effects are rash, swelling, pain in the arms or legs, back pain, bloody or cloudy urine, crack, dry or scaly skin, muscle or bone pain, frequent urge to urinate, etc.

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